Distributing Medical Wound Care Innovations

A new innovative dimension of open wound

Our Mission

Introducing
PATHELEN® Wound Powder

PATHELEN® Wound Powder is a combination of active ingredients, which are made of different pyrogenic silica, reducing the healing time of chronic wounds by eliminating the biofilm, especially multi-resistant germs and offers a cost-effective alternative to the current treatment options for wounds.

wound

THE PROBLEM

The burden of chronic wounds on the Healthcare systems

Among the most common chronic wounds are venous leg ulcers, diabetic foot syndrome and pressure ulcers. Besides the already high costs of the respective standard treatment of wounds usually infected with microbes, requiring the additional use of antibiotics.

THE PROBLEM

Anti-microbial resistance:
a global public health problem​

Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. (WHO, 2020)

Antimicrobial resistance is accelerating due to overuse of antimicrobials.

The healthcare costs are higher among those with resistant infections

“Antimicrobial resistance is a crisis that must be managed with the utmost urgency. As the world enters the ambitious new era of sustainable development, we cannot allow hard-won gains for health to be eroded by the failure of our mainstay medicines.” (Global Action plan on antimicrobial resistance, WHO report, 2015)

Reference: WHO 2020

THE PROBLEM

Antibiotics are not the answer

When there is a high risk of infection or significant loss of tissue, wounds may be left open to heal by the growth of new tissue (termed “healing by secondary intention”).

Systemic or topical antibacterial agents are used for the treatment of surgical wounds healing by secondary intention.

BUT

“There is no robust evidence on the relative effectiveness of any antiseptic/antibiotic/anti-bacterial preparation evaluated for use on surgical wounds healing by secondary intention” Cochrane Database Sys Rev 2016(3): CD11712

“Systematic reviews and meta-analyses have identified little good quality evidence from randomised controlled trials (RCTs) to support the use of advanced or antimicrobial dressings (such as iodine, honey or silver dressings) for chronic wounds” (NICE chronic wound guidance, 2016)

THE PROBLEM

Wounds and the biofilm

Biofilms are composites of bacterial cells, encased in an extracellular matrix composed of hydrated polymers and debris that create a shield against the
host’s immune cells.

Chronic wounds represent an ideal environment for biofilm formation since the necrotic tissue and debris allow bacterial attachment

Up to 60% of chronic wounds contain a biofilm1

A biofilm impairs wound healing and is resistant to antimicrobial therapy2

THE SOLUTION

PATHELEN® Wound Powder is the first ‘One-step solution’ for efficient removal of the biofilm.

PATHELEN® Wound Powder is a wound therapy that combines hydrophilic and hydrophobic pyrogenic silica. The extremely large surface structure of pyrogenic silica (1 bottle of Pathelen Wound Powder contains 2g with a surface of approx. 600m2) generates an extremely high capillary action that adsorbs wound exudate, bacterial endotoxins and in doing so, disrupts the biofilm, thereby ensuring a fast and efficient physical cleansing of the wound.

PATHELEN® Wound Powder thus “de-toxifies” and cleans the wound.

PATHELEN® Wound Powder is not antibacterial but withdraws water from a bacterial biofilm, disrupting its structure and allowing the host’s immune system to gain entry and destroy the micro-organisms present.

PATHELEN®
Woundpowder and PATHELEN®
Hybrid are the same product.

PATHELEN®
is sold under the PATHELEN®
Wound Powder name in Ghana & Nigeria only.

Due to its mode of action, PATHELEN® Wound Powder is able to treat a WIDE range of acute and chronic wounds.

PATHELEN® Wound Powder is a Medical Class I Device (CE) registered with the EMA (European Medical Agency) and the United States FDA

PATHELEN® Wound Powder has been shown to be effective against*

PATHELEN® Wound Powder works most efficiently when a biofilm is present on the wound. It should not be used if there are obvious signs of infection i.e., erythema, swelling, warmth, beyond the wound

*Based on numerous independent case studies/reports

INGREDIENTS DESCRIPTION

Aerosil 300 Pharma

Aerosil R972 Pharma

Benzalkonium Chloride

APPLICATION

PROCESS

Type 2 diabetes mellitus,
abscess of the left tibia

STEP 1

Remove any
bandages,
plasters etc.

STEP 2

Apply Wound Cleaning/Debridement

STEP 3

Dry the wound
surface with
sterile gauze

STEP 4

Shake the 50 ml bottle
for 10 seconds (the
powder will grow in
density)

STEP 5

Apply PATHELEN® Hybrid in a uniform layer with a thickness of 3 to 5 mm.

STEP 6

Add further treatment following point 1 to 5 after 24 hours.

7 days later

Infection eliminated.
Start of active granulation

11 days later

Full coverage of the wound by granulation tissues. Start of epithelisation. Termination of Pathelen Treatment

PATHELEN® Wound Powder

Pathelen has a unique mode of action due to the presence of both hydrophilic and hydrophobic silica, which enables physical adsorption of micro-organisms, toxic bacterial proteins and exudate from the wound.

MANAGEMENT OF WOUNDS

707 PATIENTS​

4 Months

$6,530 TO $14,6301

PATHELEN® is cost-effective & reduces healing time

In a series of 23 case studies using Pathelen for various wounds including:

Average healing time*

8.45 Days

Average cost**

$ 253.50

CASE STUDIES

Patient: Anonymous, 55 y.o.

Injury:

Diagnosis : Avulsion injury of the right side of face. Injury resulted in the loss of tissue on the right side of face. There was complete loss of cheek wound communicated with the oral mucosa.

Wounds were required to granulate and or were required to heal by secondary intention with epithelialization.

Local treatment:

Selected wounds were thoroughly cleaned with Savlon and copiously irrigated with saline. Pathelen was applied to the wound. Vasaline gauze was applied to hold the Pathelen in place, dry gauze was applied, and wound was bangaded lightly with gauze bandage. Dressing was changed every 48 hours.

By day 10 of Pathelen dressings the wound had filled up with granulation tissue with remarkable wound contraction. As a result, will not require the use of a flap to cover the wound she will require a simple split thickness skin graft to cover the wound.

CASE STUDIES

Patient: Jacob A., 28 y.o.

Injury:

Diagnosis : open right leg injury, debridement and external fixation done on same-day admission. Extensive laceration over the dorsum of the foot with foul odour, exudate and heavy slough over the surface of the wound.

The wound was initially cleansed with normal saline and covered with iodine solution. Unfortunately, wound healing process was slow.

Local treatment:

The wound was cleansed with normal saline and Pathelen WoundPowder was applied onto the wound.

Dressing changes were done daily, and the wound showed drastic improvement within few days. There was no foul odour and no discharge.

CASE STUDIES

Patient: Oleksii T., 41 y.o.

Disease history:​

Acute rotten pelviorectal abscess. Diabetes mellitus for 2 years.
Hospitalized after 7 days the disease has begun.

Leucocytes - 15,5 x 109/I. Sugar in blood - 8,0 mol/l

Local treatment:

Necrectomy by Pathelen® Debridement of wound surface by surgical removal and Pathelen®, autodermoplastics.

CASE STUDIES

Patient: Z.V., 68 Y.o.

Diagnosis:

Type 2 diabetes mellitus, diabetic foot syndrome neuroischemic form; wound infection of the left foot after amputation of fingers Case relevant history: Ischemic heart disease Hypertensive heart disease; Heart failure Atrial fibrillation is a permanent form

Microflora:

Staphylococcus aureus Staphylococcus epidermidis Enterococcus faecium

Blood tests:

White blood cells (WBCs): 8,0×109 /l Banded neutrophils – 8%. On the lateral surface of the left foot was observed infected wound sized 9 х 3 cm

CASE STUDIES

Patient: Vasiliy S., 69 y.o.

Diagnosis History:

Hypopharynx cancer metastasis and neck lymph nodes on the right.

1 year ago - laryngectomy with resection of the hypopharynx. After surgery - course of radiation therapy.

On the 4th day after surgery:
- Massive post-surgery lymphorrhea - MRSA-infected wound
-Necrosus of skin patches: defect of skin 8x10 cm - Denudation of carotid artery in the wound

Treatment:

Debridement of wound surface by surgical removal and Pathelen®, autodermoplatics.

Could you imagine a world without PATHELEN® Wound Powder?

Distributing Medical Wound Care Innovations

Distributing Medical Wound Care Innovations

A new innovative dimension of open wound

Introducing
PATHELEN® Wound Powder

PATHELEN® Wound Powder is a combination of active ingredients, which are made of different pyrogenic silica, reducing the healing time of chronic wounds by eliminating the biofilm, especially multi-resistant germs and offers a cost-effective alternative to the current treatment options for wounds.

THE PROBLEM

The burden of chronic wounds on the Healthcare systems

Among the most common chronic wounds are venous leg ulcers, diabetic foot syndrome and pressure ulcers. Besides the already high costs of the respective standard treatment of wounds usually infected with microbes, requiring the additional use of antibiotics.

THE PROBLEM

Anti-microbial resistance:
a global public health problem​

Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. (WHO, 2020)

Antimicrobial resistance is accelerating due to overuse of antimicrobials.

The healthcare costs are higher among those with resistant infections

“Antimicrobial resistance is a crisis that must be managed with the utmost urgency. As the world enters the ambitious new era of sustainable development, we cannot allow hard-won gains for health to be eroded by the failure of our mainstay medicines.” (Global Action plan on antimicrobial resistance, WHO report, 2015)

Reference: WHO 2020

THE PROBLEM

Antibiotics are not the answer

When there is a high risk of infection or significant loss of tissue, wounds may be left open to heal by the growth of new tissue (termed “healing by secondary intention”).

Systemic or topical antibacterial agents are used for the treatment of surgical wounds healing by secondary intention.

BUT

“There is no robust evidence on the relative effectiveness of any antiseptic/antibiotic/anti-bacterial preparation evaluated for use on surgical wounds healing by secondary intention” Cochrane Database Sys Rev 2016(3): CD11712

“Systematic reviews and meta-analyses have identified little good quality evidence from randomised controlled trials (RCTs) to support the use of advanced or antimicrobial dressings (such as iodine, honey or silver dressings) for chronic wounds” (NICE chronic wound guidance, 2016)

THE PROBLEM

Wounds and the biofilm

Biofilms are composites of bacterial cells, encased in an extracellular matrix composed of hydrated polymers and debris that create a shield against the host’s immune cells

Chronic wounds represent an ideal environment for biofilm formation since the necrotic tissue and debris allow bacterial attachment

Up to 60% of chronic wounds contain a biofilm1

A biofilm impairs wound healing and is resistant to antimicrobial therapy2

THE SOLUTION

PATHELEN® Wound Powder is the first ‘One-step solution’ for efficient removal of the biofilm.

PATHELEN® Wound Powder is a wound therapy that combines hydrophilic and hydrophobic pyrogenic silica. The extremely large surface structure of pyrogenic silica (1 bottle of Pathelen Wound Powder contains 2g with a surface of approx. 600m2) generates an extremely high capillary action that adsorbs wound exudate, bacterial endotoxins and in doing so, disrupts the biofilm, thereby ensuring a fast and efficient physical cleansing of the wound.

PATHELEN® Wound Powder thus “de-toxifies” and cleans the wound.

PATHELEN® Wound Powder is not antibacterial but withdraws water from a bacterial biofilm, disrupting its structure and allowing the host’s immune system to gain entry and destroy the micro-organisms present.

PATHELEN®
Woundpowder and PATHELEN®
Hybrid are the same product.

PATHELEN® is sold under the PATHELEN® Wound Powder name in Ghana & Nigeria only.

Due to its mode of action, PATHELEN® Hybrid is able to treat a WIDE range of acute and chronic wounds.

PATHELEN® Hybrid is a Medical Class I Device (CE) registered with the EMA (European Medical Agency) and the United States FDA

PATHELEN® Wound Powder has been shown to be effective against*

PATHELEN® Wound Powder works most efficiently when a biofilm is present on the wound. It should not be used if there are obvious signs of infection i.e., erythema, swelling, warmth, beyond the wound

*Based on numerous independent case studies/reports

INGREDIENTS DESCRIPTION

Aerosil 300 Pharma

Aerosil R972 Pharma

Benzalkonium Chloride

APPLICATION

PROCESS

Type 2 diabetes mellitus, abscess of the left tibia

STEP 1

Remove any bandages, plasters etc.

STEP 2

Apply Wound Cleaning/Debridement

STEP 3

Dry the wound surface with sterile gauze

STEP 4

Shake the 50 ml bottle for 10 seconds (the powder will grow in density)

STEP 5

Apply PATHELEN® Hybrid in a uniform layer with a thickness of 3 to 5 mm.

STEP 6

Add further treatment following point 1 to 5 after 24 hours.

7 days later

Infection eliminated.
Start of active granulation

11 days later

Full coverage of the wound by granulation tissues. Start of epithelisation. Termination of Pathelen Treatment

PATHELEN® Wound Powder

Pathelen has a unique mode of action due to the presence of both hydrophilic and hydrophobic silica, which enables physical adsorption of micro-organisms, toxic bacterial proteins and exudate from the wound.

MANAGEMENT OF WOUNDS

707 PATIENTS​

4 Months

$6,530 TO $14,6301

PATHELEN® is cost-effective & reduces healing time

In a series of 23 case studies using PATHELEN®
for various wounds including:

Average healing time*

8.45 Days

Average cost**

$250.53

CASE STUDIES

Patient: Anonymous, 55 y.o.

Injury:

Diagnosis : Avulsion injury of the right side of face. Injury resulted in the loss of tissue on the right side of face. There was a complete loss of cheek wound communicated with the oral mucosa.

Wounds were required to granulate and or were required to heal by secondary intention with epithelialization.

Local treatment:

Selected wounds were thoroughly cleaned with Savlon and copiously irrigated with saline. Pathelen was applied to the wound. Vaseline gauze was applied to hold the Pathelen in place, dry gauze was applied, and wound was bandaged lightly with gauze bandage. Dressing was changed every 48 hours.

By day 10 of Pathelen dressings the wound had filled up with granulation tissue with remarkable wound contraction. As a result, will not require the use of a flap to cover the wound she will require a simple split thickness skin graft to cover the wound.

CASE STUDIES

Patient: Jacob A., 28 y.o.

Injury:

Diagnosis : open right leg injury, debridement and external fixation done on same-day admission. Extensive laceration over the dorsum of the foot with foul odour, exudate and heavy slough over the surface of the wound.

The wound was initially cleansed with normal saline and covered with iodine solution. Unfortunately, wound healing process was slow.

Local treatment:

The wound was cleansed with normal saline and Pathelen WoundPowder was applied onto the wound.

Dressing changes were done daily, and the wound showed drastic improvement within few days. There was no foul odour and no discharge.

CASE STUDIES

Patient: Oleksii T., 41 y.o.

Disease history:​

Acute rotten pelviorectal abscess. Diabetes mellitus for 2 years.
Hospitalized after 7 days the disease has begun.

Leucocytes - 15,5 x 109/I. Sugar in blood - 8,0 mol/l

Local treatment:

Necrectomy by Pathelen® Debridement of wound surface by surgical removal and Pathelen®, autodermoplastics.

CASE STUDIES

Patient: Oleksii T., 41 y.o.

Diagnosis:

Type 2 diabetes mellitus, diabetic foot syndrome neuroischemic form; wound infection of the left foot after amputation of fingers Case relevant history: Ischemic heart disease Hypertensive heart disease; Heart failure Atrial fibrillation is a permanent form

Microflora:

Staphylococcus aureus Staphylococcus epidermidis Enterococcus faecium

Blood tests:

White blood cells (WBCs): 8,0×109 /l Banded neutrophils – 8%. On the lateral surface of the left foot was observed infected wound sized 9 х 3 cm

CASE STUDIES

Patient: Vasiliy S., 69 y.o.

Diagnosis History:

Hypopharynx cancer metastasis and neck lymph nodes on the right.

1 year ago - laryngectomy with resection of the hypopharynx. After surgery - course of radiation therapy.

On the 4th day after surgery:
- Massive post-surgery lymphorrhea - MRSA-infected wound
-Necrosus of skin patches: defect of skin 8x10 cm - Denudation of carotid artery in the wound

Treatment:

Debridement of wound surface by surgical removal and Pathelen®, autodermoplatics.

Could you imagine a world without PATHELEN® Wound Powder?

Distributing Medical Wound Care Innovations